Therapeutic potential of Annona senegalensis Pers (Annonaceae), a plant used in traditional medicine for the treatment of epilepsy in Burkina Faso

Annona senegalensis Pers. is a plant used in Burkina folkloric medicine for the treatment of epilepsy. The stem-bark, roots and leaves A. are an array human disorders, including Previous studies have demonstrated some genuine effects fractions vivo models temporal lobe In present work, we compared pharmacological profile most promising fraction obtained up-to-date with anticonvulsant drugs targeting voltage-activated channels namely Carbamazepine (Na+ channels) Retigabine (KCNQ Channels). vitro model epilepsy, could observe dose-dependent reduction electrically evoked epileptiform bursts CA1 region rat hippocampus when applying carbamazepine, retigabine or F4 senegalensis. intrinsic excitability pyramidal neurons was dose-dependently reduced by Since not anymore be observed endogenous voltage-dependent sodium were blocked restored dynamic clamp amplifier, it concluded that contains molecules target channels. Key words: Hippocampus, senegalensis, Faso extracts, channel, KCNQ M-current, retigabine, carbamazepine.